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Loss-of-function <i>ROX1</i> mutations suppress the fluconazole susceptibility of <i>upc2A</i> Δ mutation in <i>Candida glabrata</i> , implicating additional positive regulators of ergosterol biosynthesis

2021-10-10

Abstract excerpt

Two of the major classes of antifungal drugs in clinical use target ergosterol biosynthesis. Despite its importance, our understanding of the transcriptional regulation of ergosterol biosynthesis genes in pathogenic fungi is essentially limited to the role of hypoxia and sterol-stress induced transcription factors such as Upc2 and Upc2A as well as homologs of Sterol Response Element Binding (SREB) factors. To iden...

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Literature Corpus work
9405c33f-20a5-53d8-943c-514ceb66f359
DOI
10.1101/2021.10.07.463606
Open publication

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Loss-of-function <i>ROX1</i> mutations suppress the fluconazole susceptibility of <i>upc2A</i> Δ mutation in <i>Candida glabrata</i> , implicating additional positive regulators of ergosterol biosynthesisDOI 10.1101/2021.10.07.463606
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