Article

A Mechanism Driving Echinocandin Heteroresistance in <i>Candida glabrata</i>

2026-04-16

Abstract excerpt

<h4>ABSTRACT</h4> While pathogenic fungi can acquire resistance to the current arsenal of antifungals through genetic mutations, heteroresistance has emerged as an important new cause of therapeutic failures. Heteroresistance is generally thought to arise in small subpopulations that display phenotypic resistance to antifungals without genetic mutations. This study blurs that line by showing gain-of-resistance mu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 683aeeeb-ee06-56e1-9739-f85550e181d9
DOI: 10.64898/2026.04.16.718912

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Mechanism Driving Echinocandin Heteroresistance in <i>Candida glabrata</i>DOI 10.64898/2026.04.16.718912Read

<i>FKS1/2</i> -variant independent mechanisms underlying the emergence of resistance in echinocandin-refractory <i>Candida auris</i> infectionsSemantic proximity Read

Redefining Pleiotropic Drug Resistance in a Pathogenic Yeast: Pdr1 Functions as a Sensor of Cellular Stresses in <i>Candida glabrata</i>Semantic proximity Read

Insight into the Mechanisms and Clinical Relevance of Antifungal HeteroresistanceSemantic proximity Read

Insight into the Mechanisms and Clinical Relevance of Antifungal HeteroresistanceSemantic proximity Read

Micafungin exposure drives multidrug resistance in <i>Clavispora lusitaniae</i>Semantic proximity Read

Redefining pleiotropic drug resistance in a pathogenic yeast: Pdr1 functions as a sensor of cellular stresses in Candida glabrataSemantic proximity Read

<i>Candida glabrata YPK2</i> is a multidrug susceptibility locusSemantic proximity Read

Polygenetic Determinants of Azole Resistance, Tolerance, and Heteroresistance in <i>Candida albicans</i>Semantic proximity Read

Functional analysis of the Candida albicans kinome reveals Hrr25 as a regulator of antifungal susceptibilitySemantic proximity Read

Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida SpeciesSemantic proximity Read

Echinocandin heteroresistance causes prophylaxis failure and facilitates breakthrough<i>Candida parapsilosis</i>infectionSemantic proximity Read

Identification of essential genes and fluconazole resistance genes in <i>Candida glabrata</i> by profiling of <i>Hermes</i> transposon insertionsSemantic proximity Read