Candida glabrata maintains two HAP1 ohnologs, HAP1A and HAP1B , for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and hypoxic conditions

Abstract excerpt

ABSTRACT Candida glabrata exhibits innate resistance to azole antifungal drugs but also has the propensity to rapidly develop clinical drug resistance. Azole drugs, which target Erg11, is one of the major classes of antifungals used to treat Candida infections. Despite their widespread use, the mechanism controlling azole-induced ERG gene expression and drug resistance in C. glabrata has primarily revolved around...

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