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Azole resistance is mediated by integration of sterol gene regulation and membrane transporter production by the zinc cluster-containing transcription factor Upc2A in <i>Candida glabrata</i>

2021-05-08

Abstract excerpt

The most commonly used antifungal drugs are the azole compounds that interfere with biosynthesis of the fungal-specific sterol: ergosterol. The pathogenic yeast Candida glabrata commonly acquires resistance to azole drugs like fluconazole via mutations in a gene encoding a transcription factor called PDR1 . These PDR1 mutations lead to overproduction of drug transporter proteins like the ATP-binding cassette tr...

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Literature Corpus work
936bff14-8eef-555a-9e99-0c8081910f75
DOI
10.1101/2021.05.07.443069
Open publication

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Azole resistance is mediated by integration of sterol gene regulation and membrane transporter production by the zinc cluster-containing transcription factor Upc2A in <i>Candida glabrata</i>DOI 10.1101/2021.05.07.443069
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