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<i>Candida glabrata</i> maintains two Hap1 homologs, Zcf27 and Zcf4, for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and hypoxic conditions

2024-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Candida glabrata exhibits innate resistance to azole antifungal drugs but also has the propensity to rapidly develop clinical drug resistance. Azole drugs, which target Erg11, is one of the three major classes of antifungals used to treat Candida infections. Despite their widespread use, the mechanism controlling azole-induced ERG gene expression and drug resistance in C. glabrata has primari...

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Literature Corpus work
004ddf32-36c4-527c-a3e8-a8df0de38b85
DOI
10.1101/2024.06.20.599910
Open publication

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<i>Candida glabrata</i> maintains two Hap1 homologs, Zcf27 and Zcf4, for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and hypoxic conditionsDOI 10.1101/2024.06.20.599910
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