Article

Multiple mechanisms impact fluconazole resistance of mutant Erg11 proteins in Candida glabrata

2021-06-24

Abstract excerpt

Azoles, the most commonly used antifungal drugs, specifically inhibit the fungal lanosterol α-14 demethylase enzyme, which is referred to as Erg11. Inhibition of Erg11 ultimately leads to a reduction in ergosterol production, an essential fungal membrane sterol. Many Candida species, such as Candida albicans , develop mutations in this enzyme which reduces the azole binding affinity and results in increased resi...

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Literature Corpus work: bfc08177-da4e-580b-914a-e5d7ed57595d
DOI: 10.1101/2021.06.23.449691

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