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Genetic interaction analysis of Candida glabrata transcription factors CST6 and UPC2A in the regulation of respiration and fluconazole susceptibility.

Antimicrobial agents and chemotherapy - 13 Feb 2025

Ollinger Tomye L, Zarnowski Robert, Parker Josie E, Kelly Steven L, Andes David R, Stamnes Mark A, Krysan Damian J

Abstract excerpt

Candida glabrata is the second most common cause of invasive candidiasis and is widely known to have reduced susceptibility to fluconazole relative to many other Candida spp. Upc2A is a transcription factor that regulates ergosterol biosynthesis gene expression under conditions of sterol stress such as azole drug treatment or hypoxia. Through an in vitro microevolution experiment, we found that loss-of-function...

Topics

Candida glabrata
Fluconazole
Antifungal Agents
Fungal Proteins
Transcription Factors
Gene Expression Regulation, Fungal
Microbial Sensitivity Tests
Drug Resistance, Fungal
Ergosterol
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 39714155
DOI: 10.1128/aac.01294-24
PMCID: PMC11823675

Genes

CST6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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