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Rfg1, a Protein Related to the <i>Saccharomyces cerevisiae</i> Hypoxic Regulator Rox1, Controls Filamentous Growth and Virulence in <i>Candida albicans</i>

1 Apr 2001

Abstract excerpt

Candida albicans, the major fungal pathogen in humans, can undergo a reversible transition from ellipsoidal single cells (blastospores) to filaments composed of elongated cells attached end to end. This transition is thought to allow for rapid colonization of host tissues, facilitating the spread of infection. Here, we report the identification of Rfg1, a transcriptional regulator that controls filamentous growth...

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PMID: 11259598
DOI: 10.1128/mcb.21.7.2496-2505.2001

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