Article
Loss-of-Function ROX1 Mutations Suppress the Fluconazole Susceptibility of upc2AΔ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis.
mSphere - 22 Dec 2021
Ollinger Tomye L, Vu Bao, Murante Daniel, Parker Josie E, Simonicova Lucia, Doorley Laura, Stamnes Mark A, Kelly Steven L, Rogers P David, Moye-Rowley W Scott, Krysan Damian J
Abstract excerpt
Two of the major classes of antifungal drugs in clinical use target ergosterol biosynthesis. Despite its importance, our understanding of the transcriptional regulation of ergosterol biosynthesis genes in pathogenic fungi is essentially limited to the role of hypoxia and sterol-stress-induced transcription factors such as Upc2 and Upc2A as well as homologs of sterol response element binding (SREB) factors. To...
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