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Article

A protocol for simultaneous high-sensitivity genotyping and chromatin accessibility profiling in single cells.

STAR protocols - 15 Dec 2023

Turkalj Sven, Jakobsen Niels Asger, Groom Angus, Radtke Felix A, Vyas Paresh

Abstract excerpt

Single-cell assay for transposase-accessible chromatin with sequencing (scATAC-seq) resolves the heterogeneity of epigenetic states across cells but does not typically capture exonic mutations, which limits our knowledge of how somatic mutations alter chromatin landscapes. Here, we present a plate-based approach coupling high-sensitivity genotyping of genomic loci with high-content scATAC-seq libraries from the...

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Identifiers

PMID: 37897733
DOI: 10.1016/j.xpro.2023.102641
PMCID: PMC10641301

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