Article

Spatial RNA sequencing identifies robust markers of vulnerable and resistant human midbrain dopamine neurons and their expression in Parkinson’s Disease

2018-05-31

Abstract excerpt

<h4>ABSTRACT</h4> Defining transcriptional profiles of substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) dopamine neurons is critical to understanding their differential vulnerability in Parkinson’s Disease (PD). Here, we determine transcriptomes of human SNc and VTA dopamine neurons using LCM-seq on a large sample cohort. We apply a bootstrapping strategy as sample input to DESeq2 and identif...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93b19bbd-ebdb-5e87-b010-7f14c7b64382
DOI: 10.1101/334417

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial RNA sequencing identifies robust markers of vulnerable and resistant human midbrain dopamine neurons and their expression in Parkinson’s DiseaseDOI 10.1101/334417Read

LCM-seq identifies robust markers of vulnerable and resistant human midbrain dopamine neuronsSemantic proximity Read

Deciphering Regional Transcriptomic Alterations in a 6-OHDA Rat Model of Parkinson's Disease through Integrated Single Cell and Spatial AnalysesSemantic proximity Read

A molecular atlas of cell-type specific signatures in the parkinsonian striatumSemantic proximity Read

Human‐Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine NeuronsSemantic proximity Read

Transcriptomic atlas of midbrain dopamine neurons uncovers differential vulnerability in a Parkinsonism lesion modelSemantic proximity Read

Single-cell transcriptomic atlas of the human substantia nigra in Parkinson’s diseaseSemantic proximity Read

Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseasesSemantic proximity Read

Cell-Type-Resolved Transcriptional Remodelling in Parkinson’s Disease Substantia Nigra: An Integrated Framework Implicates NPAS3 and BNC2 Regulatory Subnetworks in Dopaminergic Neurons and Glial SubpopulationsSemantic proximity Read

Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2 <sup>G2019S</sup> model of Parkinson’s diseaseSemantic proximity Read

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disordersSemantic proximity Read

A human single-cell atlas of the Substantia nigra reveals novel cell-specific pathways associated with the genetic risk of Parkinson’s disease and neuropsychiatric disordersSemantic proximity Read

A molecular census of midbrain dopaminergic neurons in Parkinson’s diseaseSemantic proximity Read