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Article

Human‐Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine Neurons

13 Mar 2020

Abstract excerpt

OBJECTIVE: Neuronal loss in the substantia nigra pars compacta (SNpc) in Parkinson disease (PD) is not uniform, as dopamine neurons from the ventral tier are lost more rapidly than those of the dorsal tier. Identifying the intrinsic differences that account for this differential vulnerability may provide a key for developing new treatments for PD. METHODS: Here, we compared the RNA-sequenced transcriptomes of...

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PMID: 32167609
DOI: 10.1002/ana.25719

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