Article

Single nuclei RNAseq stratifies multiple sclerosis patients into distinct white matter glial responses

2022-04-09

Abstract excerpt

The lack of understanding of the cellular and molecular basis of clinical and genetic heterogeneity in progressive multiple sclerosis (MS) has hindered the search for new effective therapies. Here, to address this gap, we analysed 632,000 single nuclei RNAseq profiles of 156 brain tissue samples, comprising white matter (WM) lesions, normal appearing WM, grey matter (GM) lesions and normal appearing GM from 54 MS...

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Literature Corpus work: cb91fc9c-888b-59fc-a7e2-6e6631c6bc3a
DOI: 10.1101/2022.04.06.487263

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