Article

CRISPR-induced exon skipping of β-catenin reveals tumorigenic mutants driving distinct subtypes of liver cancer

2022-03-27

Abstract excerpt

CRISPR/Cas9-driven cancer modeling studies are based on disruption of tumor suppressor genes (TSGs) by small insertions or deletions (indels) that lead to frame-shift mutations. In addition, CRISPR/Cas9 is widely used to define the significance of cancer oncogenes and genetic dependencies in loss-of function studies. However, how CRISPR/Cas9 influences gain-of-function oncogenic mutations is elusive. Here, we demo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 937874c5-98a3-558e-bb94-a9fc9743d1f7
DOI: 10.1101/2022.03.27.485965

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CRISPR-induced exon skipping of β-catenin reveals tumorigenic mutants driving distinct subtypes of liver cancerDOI 10.1101/2022.03.27.485965Read

Deleting the β-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or hepatoblastoma-like tumor growth.Semantic proximity Read

Deleting <i>in vivo</i> β-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or hepatoblastoma-like tumorsSemantic proximity Read

Intrinsic Activation of β-catenin Signaling by CRISPR/Cas9-mediated Exon Skipping Contributes to Immune Evasion in Hepatocellular CarcinomaSemantic proximity Read

Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma.Semantic proximity Read

<i>DNAJB1</i> - <i>PRKACA</i> fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinomaSemantic proximity Read

Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening.Semantic proximity Read

CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma.Semantic proximity Read

Therapeutic potential of SOX9 dysruption in Combined Hepatocellular Carcinoma-CholangiocarcinomaSemantic proximity Read

CRISPR-mediated direct mutation of cancer genes in the mouse liver.Semantic proximity Read

Exploring the Impact of the β-Catenin Mutations in Hepatocellular Carcinoma: An In-Depth Review.Semantic proximity Read

CRISPR activation screening in a mouse model for drivers of hepatocellular carcinoma growth and metastasisSemantic proximity Read

Murine Liver Organoids as a Genetically Flexible System to Study Liver Cancer In Vivo and In VitroSemantic proximity Read