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Article

Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening.

Science advances - 1 Feb 2018

Wang Guangchuan, Chow Ryan D, Ye Lupeng, Guzman Christopher D, Dai Xiaoyun, Dong Matthew B, Zhang Feng, Sharp Phillip A, Platt Randall J, Chen Sidi

Abstract excerpt

Cancer genomics consortia have charted the landscapes of numerous human cancers. Whereas some mutations were found in classical oncogenes and tumor suppressors, others have not yet been functionally studied in vivo. To date, a comprehensive assessment of how these genes influence oncogenesis is lacking. We performed direct high-throughput in vivo mapping of functional variants in an autochthonous mouse model of...

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Identifiers

PMID: 29503867
DOI: 10.1126/sciadv.aao5508
PMCID: PMC5829971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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