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Article

Murine Liver Organoids as a Genetically Flexible System to Study Liver Cancer In Vivo and In Vitro

5 Feb 2019

Abstract excerpt

The rising incidence of cholangiocarcinoma (CCA) coupled with a low 5‐year survival rate that remains below 10% delineates the urgent need for more effective treatment strategies. Although several recent studies provided detailed information on the genetic landscape of this fatal malignancy, versatile model systems to functionally dissect the immediate clinical relevance of the identified genetic alterations are...

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PMID: 30859153
DOI: 10.1002/hep4.1312

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