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Article

Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma.

Scientific reports - 24 Aug 2021

Akasu Masafumi, Shimada Shu, Kabashima Ayano, Akiyama Yoshimitsu, Shimokawa Masahiro, Akahoshi Keiichi, Kudo Atsushi, Yamaoka Shoji, Tanabe Minoru, Tanaka Shinji

Abstract excerpt

Comprehensive analysis of clinical samples has recently identified molecular and immunological classification of hepatocellular carcinoma (HCC), and the CTNNB1 (β-catenin)-mutated subtype exhibits distinctive characteristics of immunosuppressive tumor microenvironment. For clarifying the molecular mechanisms, we first established human and mouse HCC cells with exon 3 skipping of β-catenin, which promoted nuclear...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34429454
DOI: 10.1038/s41598-021-96167-0
PMCID: PMC8384852

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Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma.PMID 34429454Read ↗

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