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<i>DNAJB1</i> - <i>PRKACA</i> fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma

2017-09-21

Abstract excerpt

A segmental deletion resulting in DNAJB1-PRKACA gene fusion is now recognized as the signature genetic event of fibrolamellar hepatocellular carcinoma (FL-HCC), a rare but lethal liver cancer that primarily affects adolescents and young adults. Here, we implement CRISPR/Cas9 genome editing and transposon-mediated somatic gene transfer to demonstrate that expression of both the endogenous fusion protein or a chime...

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Literature Corpus work
8bf22cd5-28db-568b-805c-bd9a34f8a346
DOI
10.1101/192104
Open publication

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