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Deleting <i>in vivo</i> β-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or hepatoblastoma-like tumors

2021-07-05

Abstract excerpt

<h4>Background and aims</h4> One-third of hepatocellular carcinomas (HCCs) have mutations that activate the β-catenin pathway with mostly CTNNB1 mutations. Mouse models using Adenomatous polyposis coli ( Apc ) loss-of-functions (LOF) are widely used to mimic β-catenin-dependent tumorigenesis. Considering the low prevalence of APC mutations in human HCCs we aimed to generate hepatic tumors through CTNNB1 exon...

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Literature Corpus work
69b3e8b0-955f-579f-bee6-114d8761d43f
DOI
10.1101/2021.07.04.450836
Open publication

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Deleting <i>in vivo</i> β-catenin degradation domain in mouse hepatocytes drives hepatocellular carcinoma or hepatoblastoma-like tumorsDOI 10.1101/2021.07.04.450836
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