Article
CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma.
Gastroenterology - 1 Dec 2017
Engelholm Lars H, Riaz Anjum, Serra Denise, Dagnæs-Hansen Frederik, Johansen Jens V, Santoni-Rugiu Eric, Hansen Steen H, Niola Francesco, Frödin Morten
Abstract excerpt
BACKGROUND & AIMS: Fibrolamellar hepatocellular carcinoma (FL-HCC) is a primary liver cancer that predominantly affects children and young adults with no underlying liver disease. A somatic, 400 Kb deletion on chromosome 19 that fuses part of the DnaJ heat shock protein family (Hsp40) member B1 gene (DNAJB1) to the protein kinase cAMP-activated catalytic subunit alpha gene (PRKACA) has been repeatedly identified...
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