Article

Therapeutic potential of SOX9 dysruption in Combined Hepatocellular Carcinoma-Cholangiocarcinoma

2024-05-23

Abstract excerpt

<h4>ABSTRACT</h4> Combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CCA) represents a challenging subtype of primary liver cancer with limited treatment options and a poor prognosis. Recently, we and others have highlighted the context-dependent roles of the biliary-specific transcription factor SOX9 in the pathogenesis of liver cancers using various Cre applications in Sox9 (flox/flox) strains, to ach...

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Literature Corpus work: 090610c1-3f06-559b-a5e4-7b7c85fa510d
DOI: 10.1101/2024.05.22.595319

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