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CRISPR activation screening in a mouse model for drivers of hepatocellular carcinoma growth and metastasis

2 Feb 2023

Abstract excerpt

Hepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality worldwide. Here we described a genome-wide screen by CRISPR activation (CRISPRa) library in vivo for drivers of HCC growth and metastasis. Pathological results showed the cell population formed highly metastatic tumors in lung after being mutagenized with CRISPRa. In vitro validation indicated overexpression of XAGE1B, PLK4, LMO1 and...

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PMID: 36843840
DOI: 10.1016/j.isci.2023.106099

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