Article

Changes in gene expression shift and switch genetic interactions

2019-03-14

Abstract excerpt

<h4>Summary</h4> An important goal in disease genetics and evolutionary biology is to understand how mutations combine to alter phenotypes and fitness. Non-additive interactions between mutations occur extensively and change across conditions, cell types, and species, making genetic prediction a difficult challenge. To understand the reasons for this, we reduced the problem to a minimal system where we combined m...

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Identifiers and source

Literature Corpus work: 936387ee-f3d1-5074-91b4-7041e488ed50
DOI: 10.1101/578419

Open publication

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