Article
Higher-order epistasis and phenotypic prediction.
Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2022
Zhou Juannan, Wong Mandy S, Chen Wei-Chia, Krainer Adrian R, Kinney Justin B, McCandlish David M
Abstract excerpt
Contemporary high-throughput mutagenesis experiments are providing an increasingly detailed view of the complex patterns of genetic interaction that occur between multiple mutations within a single protein or regulatory element. By simultaneously measuring the effects of thousands of combinations of mutations, these experiments have revealed that the genotype-phenotype relationship typically reflects not only...
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