Article
On the mechanistic nature of epistasis in a canonical cis-regulatory element.
eLife - 18 May 2017
Lagator Mato, Paixão Tiago, Barton Nicholas H, Bollback Jonathan P, Guet Călin C
Abstract excerpt
Understanding the relation between genotype and phenotype remains a major challenge. The difficulty of predicting individual mutation effects, and particularly the interactions between them, has prevented the development of a comprehensive theory that links genotypic changes to their phenotypic effects. We show that a general thermodynamic framework for gene regulation, based on a biophysical understanding of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.