Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging

Abstract excerpt

For the last few decades modern biology has focused on quantifying, understanding and mapping the genetic characteristics of cells. This genotype–driven perspective has led to significant advances in our understanding and treatment of diseases such as cancer e.g. the discovery of driver mutations and the development of molecularly–targeted therapeutics. However, this perspective has largely ignored the functional...

Topics

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• Chromosome Mapping
• Evolution, Molecular
• Genetic Association Studies
• Genetic Heterogeneity
• Genotype
• Models, Genetic
• Phenotype
• Stochastic Processes

Identifiers and source

Literature Corpus work

4dae3608-cc2e-5df7-8e35-a3d08a0de4ea

DOI

10.1101/042424