Article

Higher-order epistasis and phenotypic prediction

2020-10-15

Abstract excerpt

Contemporary high-throughput mutagenesis experiments are providing an increasingly detailed view of the complex patterns of genetic interaction that occur between multiple mutations within a single protein or regulatory element. By simultaneously measuring the effects of thousands of combinations of mutations, these experiments have revealed that the genotype-phenotype relationship typically reflects genetic inter...

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Literature Corpus work: 35b4c744-af2f-5763-83d6-2911d88c6f7a
DOI: 10.1101/2020.10.14.339804

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