Article
Genetic Causation in Complex Regulatory Systems: An Integrative Dynamic Perspective.
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jun 2020
DiFrisco James, Jaeger Johannes
Abstract excerpt
The logic of genetic discovery has changed little over time, but the focus of biology is shifting from simple genotype-phenotype relationships to complex metabolic, physiological, developmental, and behavioral traits. In light of this, the traditional reductionist view of individual genes as privileged difference-making causes of phenotypes is re-examined. The scope and nature of genetic effects in complex...
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