Genotype to phenotype mapping and the fitness landscape of the E. coli lac promoter.

doi:10.1371/journal.pone.0061570

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Article

Genotype to phenotype mapping and the fitness landscape of the E. coli lac promoter.

PloS one - 1 Jan 2013

Otwinowski Jakub, Nemenman Ilya

Abstract excerpt

Genotype-to-phenotype maps and the related fitness landscapes that include epistatic interactions are difficult to measure because of their high dimensional structure. Here we construct such a map using the recently collected corpora of high-throughput sequence data from the 75 base pairs long mutagenized E. coli lac promoter region, where each sequence is associated with its phenotype, the induced...

Topics

Algorithms
Epistasis, Genetic
Escherichia coli
Gene Expression Regulation, Bacterial
Genetic Association Studies
Genetic Fitness
Genotype
Lac Operon
Models, Genetic
Promoter Regions, Genetic

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PMID: 23650500
DOI: 10.1371/journal.pone.0061570
PMCID: PMC3641078

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