Actually, what is a gain-of-function mutation?

Abstract excerpt

For more than a century, scientists have worked to characterize, understand, and predict the consequences of mutations. For almost as long, scientists-always on the lookout for general principles-have categorized these mutations, hoping that putting them into labeled boxes might help reveal the molecular logic that governs mutational effects. Here, I will dive into one of these boxes, labeled "gain-of-function",...

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