Article

Extracellular matrices modulate differentiation of human embryonic stem cell-derived hepatocyte-like cells with spatial hepatic features

2023-07-31

Abstract excerpt

<title>Abstract</title> <p>Background Human pluripotent stem cell (hPSC)-derived hepatocyte-like cells (HLCs) can provide a valuable in vitro model for disease modelling and drug development. However, it is challenging to generate these cells with functions comparable to hepatocytes in vivo. Extracellular matrices (ECM) play an important role in supporting liver development and hepatocyte functions, but their fu...

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Literature Corpus work: c2e65061-69b8-5806-b7a3-5e32f906859e
DOI: 10.21203/rs.3.rs-3157108/v1

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