Article

Modeling Hereditary Diffuse Leukoencephalopathy with Axonal Spheroids using microglia-sufficient brain organoids

2024-02-12

Abstract excerpt

Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) is a rare, fatal, adult-onset neurodegenerative disease that is most often caused by mutations affecting the Colony Stimulating factor-1 Receptor (CSF-1R). To understand how CSF-1R-mutation affects human microglia – the specialized brain-resident macrophages of the central nervous system – and the downstream consequences for neuronal cells, we use...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 930d01e6-dee1-58b2-9ec4-335f13e29f3c
DOI: 10.1101/2024.02.12.579869

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modeling Hereditary Diffuse Leukoencephalopathy with Axonal Spheroids using microglia-sufficient brain organoidsDOI 10.1101/2024.02.12.579869Read

Modeling hereditary diffuse leukoencephalopathy with axonal spheroids using microglia-sufficient brain organoidsSemantic proximity Read

An adapted stem cell-derived microglia protocol for the study of microgliopathies and other neurological disordersSemantic proximity Read

Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy.Semantic proximity Read

A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosisSemantic proximity Read

A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosisSemantic proximity Read

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids.Semantic proximity Read

Modeling Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism–dementia Complex with Microglia Containing Cerebral Organoids Derived from Induced Pluripotent Stem CellsSemantic proximity Read

Defined human tri-lineage brain microtissuesSemantic proximity Read

Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS): update on molecular genetics.Semantic proximity Read

Human iPSC-Derived Microglia Integrate Into Cerebral Organoids and Assume an In Vivo-Like Phenotype.Semantic proximity Read

The TREM2-R47H Variant Drives Alzheimer’s-Relevant Alterations in Forebrain Organoids Beyond Microglial PopulationsSemantic proximity Read

Cellular and molecular phenotypes of <i>C9orf72</i> ALS/FTD patient derived iPSC-microglia mono-culturesSemantic proximity Read