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Article

Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy.

Acta neuropathologica communications - 19 May 2020

Kempthorne Liam, Yoon Hyejin, Madore Charlotte, Smith Scott, Wszolek Zbigniew K, Rademakers Rosa, Kim Jungsu, Butovsky Oleg, Dickson Dennis W

Abstract excerpt

Microglia are resident macrophages of the central nervous system, and their unique molecular signature is dependent upon CSF-1 signaling. Previous studies have demonstrated the importance of CSF-1R in survival and development of microglia in animal models, but the findings are of uncertain relevance to understanding the influence of CSF-1R on microglia in humans. Hereditary diffuse leukoencephalopathy with...

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Identifiers

PMID: 32430064
DOI: 10.1186/s40478-020-00947-0
PMCID: PMC7236286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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