Article

Modeling hereditary diffuse leukoencephalopathy with axonal spheroids using microglia-sufficient brain organoids

2025-05-21

Abstract excerpt

Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) is a rare, fatal, adult-onset neurodegenerative disease that is most often caused by mutations affecting the colony stimulating factor-1 receptor (CSF-1R). To understand how CSF-1R-mutation affects human microglia – the specialized brain-resident macrophages of the central nervous system – and the downstream consequences for neuronal cells, we use...

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Literature Corpus work: 0f9212d1-47ae-51bf-a16f-f6395880f1df
DOI: 10.7554/elife.96693.3

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