Article

Melody: Decoding the Sequence Determinants of Locus Specific DNA Methylation Across Human Tissues

2025-11-25

Abstract excerpt

DNA methylation is a fundamental epigenetic modification that plays crucial roles in transcriptional regulation, cellular differentiation, and genome stability. However, how locus-specific DNA methylation is determined by intrinsic DNA sequence remains poorly understood. Here, we introduce Melody, a deep learning framework that predicts DNA methylation from 10-kb genomic sequences, enabling the integration of both...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 92e6a9d1-f84f-59c7-9e6b-4a49241af417
DOI: 10.1101/2025.11.23.689975

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Melody: Decoding the Sequence Determinants of Locus Specific DNA Methylation Across Human TissuesDOI 10.1101/2025.11.23.689975Read

Dissecting sequence determinants of DNA methylation and in silico perturbationSemantic proximity Read

Predicting the effect of non-coding mutations on single-cell DNA methylation using deep learningSemantic proximity Read

A New Paradigm for Genome-wide DNA Methylation Prediction Without Methylation InputSemantic proximity Read

DeepMethylation: A deep learning framework for tissue-specific DNA methylation prediction and functional variant annotation.Semantic proximity Read

Mapping of Variable DNA Methylation Across Multiple Cell Types Defines a Dynamic Regulatory Landscape of the Human Genome.Semantic proximity Read

CpGPT: a Foundation Model for DNA MethylationSemantic proximity Read

scDNAm-GPT Captures Genome-wide CpG Dependencies in Single-cell DNA methylomes to Revolutionize Epigenetic AnalysisSemantic proximity Read

Epigenetic conditioning improves sequence-based modeling of gene regulation across cell types and allelesSemantic proximity Read

Predicting the impact of non-coding variants on DNA methylationSemantic proximity Read

Predicting the impact of non-coding variants on DNA methylation.Semantic proximity Read

Predicting Methylation from Sequence and Gene Expression Using Deep Learning with AttentionSemantic proximity Read

Human body epigenome maps reveal noncanonical DNA methylation variation.Semantic proximity Read