Article

Epigenetic conditioning improves sequence-based modeling of gene regulation across cell types and alleles

2026-06-07

Abstract excerpt

Epigenetic state modulates gene regulation in a manner not always predictable from DNA sequence alone, yet current genomic deep learning models do not leverage epigenetic state as input. We present MethylSeqNet, a model that conditions pretrained sequence embeddings on CpG methylation, a stable epigenetic mark increasingly available from long-read sequencing data. Using a novel conditioning mechanism enabling scal...

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Literature Corpus work: f205d174-8e79-518b-98a5-004ef02a2cd5
DOI: 10.64898/2026.06.02.729723

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