Article

Dissecting sequence determinants of DNA methylation and in silico perturbation

2025-11-20

Abstract excerpt

DNA methylation shapes cellular identity and genome function, yet the sequence logic that governs its establishment remains largely unresolved. Here we present MethylAI, a cross-species–pretrained and human-specialized deep learning framework that predicts single-CpG methylation states directly from genomic sequence with high fidelity. Through quantitative attribution, MethylAI uncovers intrinsic cis-regulatory pr...

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Literature Corpus work: 9446e4c1-cb63-56d3-828c-1ad5c180e5a8
DOI: 10.1101/2025.11.20.689274

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