Article

A New Paradigm for Genome-wide DNA Methylation Prediction Without Methylation Input

2025-02-08

Abstract excerpt

<h4> A bstract </h4> DNA methylation (DNAm) is a key epigenetic modification that regulates gene expression and is pivotal in development and disease. However, profiling DNAm at genome scale is challenging: of ∼28 million CpG sites in the human genome, only about 1–3% are typically assayed in common datasets due to technological limitations and cost. Recent deep learning approaches, including masking-based gene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0bd3fee2-674f-5944-bad3-b6ce7cd5770f
DOI: 10.1101/2025.02.05.636730

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A New Paradigm for Genome-wide DNA Methylation Prediction Without Methylation InputDOI 10.1101/2025.02.05.636730Read

Melody: Decoding the Sequence Determinants of Locus Specific DNA Methylation Across Human TissuesSemantic proximity Read

Dissecting sequence determinants of DNA methylation and in silico perturbationSemantic proximity Read

MethylGPT: a foundation model for the DNA methylomeSemantic proximity Read

CpGPT: a Foundation Model for DNA MethylationSemantic proximity Read

Predicting the effect of non-coding mutations on single-cell DNA methylation using deep learningSemantic proximity Read

Predicting Methylation from Sequence and Gene Expression Using Deep Learning with AttentionSemantic proximity Read

DeepMethylation: A deep learning framework for tissue-specific DNA methylation prediction and functional variant annotation.Semantic proximity Read

scDNAm-GPT Captures Genome-wide CpG Dependencies in Single-cell DNA methylomes to Revolutionize Epigenetic AnalysisSemantic proximity Read

MethylNet: An Automated and Modular Deep Learning Approach for DNA Methylation AnalysisSemantic proximity Read

Epigenetic conditioning improves sequence-based modeling of gene regulation across cell types and allelesSemantic proximity Read

MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Networks, Inspired by Capsule Networks.Semantic proximity Read

MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Network, Inspired by Capsule NetworksSemantic proximity Read