Article

Predicting the impact of non-coding variants on DNA methylation

2016-09-06

Abstract excerpt

DNA methylation plays a crucial role in the establishment of tissue-specific gene expression and the regulation of key biological processes. However, our present inability to predict the effect of genome sequence variation on DNA methylation precludes a comprehensive assessment of the consequences of non-coding variation. We introduce CpGenie, a sequence-based framework that learns a regulatory code of DNA methyla...

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Literature Corpus work: f2b73413-5b5c-5aaa-a961-f1705a89770d
DOI: 10.1101/073809

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