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scDNAm-GPT Captures Genome-wide CpG Dependencies in Single-cell DNA methylomes to Revolutionize Epigenetic Analysis

2025-02-23

Abstract excerpt

Single-cell DNA methylomes are challenging to interpret because of sparse CpG coverage and the complexity of genome-wide sequences. We present scDNAm-GPT, a universal foundation model that uses context-aware CpG tokenization, a Mamba backbone, and cross-attention to capture both local and global DNA methylation patterns. Trained on over one million single cells from 35 human and mouse tissues, scDNAm-GPT enables a...

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Identifiers and source

Literature Corpus work
9b51353b-6929-5e71-a850-98380637e11d
DOI
10.1101/2025.02.19.638959
Open publication

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scDNAm-GPT Captures Genome-wide CpG Dependencies in Single-cell DNA methylomes to Revolutionize Epigenetic AnalysisDOI 10.1101/2025.02.19.638959
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