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Article

DeepMethylation: A deep learning framework for tissue-specific DNA methylation prediction and functional variant annotation.

PLoS computational biology - 1 Jul 2026

Li Wenran, Yu Shijia, Cheng Yingyu, Wang Sijia

Abstract excerpt

DNA methylation is a key epigenetic modification that regulates gene expression and plays a vital role in cell differentiation, development, and tumorigenesis. However, large-scale experimental profiling of genome-wide DNA methylation remains time-consuming and limited in coverage. We present DeepMethylation, a deep learning framework that integrates DNA sequence and tissue-specific epigenomic features to predict...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42384754
DOI: 10.1371/journal.pcbi.1014476
PMCID: PMC13340841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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