Article

Reward Circuit Adaptations After Chronic Antipsychotic Treatment Confer Addiction Vulnerability

2026-04-28

Abstract excerpt

<h4>Objective</h4> Antipsychotics are widely used chronically to treat several psychiatric conditions and off-label indications, but their clinical utility is often accompanied by motor and/or metabolic side effects. Antipsychotics can also alter the brain’s reward circuitry, and we recently showed that upon abrupt discontinuation, chronic treatment with the first-generation antipsychotic haloperidol increases co...

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Literature Corpus work: 92b5a582-040b-5a31-adeb-07762a8160f1
DOI: 10.64898/2026.04.24.720671

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