Article

Histone deacetylase 5 in prelimbic prefrontal cortex limits context-associated cocaine seeking

2024-09-21

Abstract excerpt

<h4>Background</h4> Repeated cocaine use produces neuroadaptations that support drug craving and relapse in substance use disorders (SUDs). Powerful associations formed with drug-use environments can promote a return to active drug use in SUD patients, but the molecular mechanisms that control the formation of these prepotent drug-context associations remain unclear. <h4>Methods</h4> In the rat intravenous cocai...

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Literature Corpus work: 21622d72-3d36-5a90-8a5e-3a496bd748e0
DOI: 10.1101/2024.09.21.614125

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