Article

Negative emotional behavior during fentanyl abstinence is mediated by adaptations in nucleus accumbens neuron subtypes

2022-05-15

Abstract excerpt

<h4>Summary</h4> Opioid discontinuation generates a withdrawal syndrome marked by a negative emotional state. Increased anxiety and dysphoria during opioid discontinuation are a significant barrier to achieving long-term abstinence in opioid-dependent individuals. Adaptations in brain-reward circuitry are implicated in the opioid abstinence syndrome, but current knowledge is limited to changes following natural a...

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Literature Corpus work: 18f7d0ef-9437-5dc0-b788-14ecbfa4ff70
DOI: 10.1101/2022.05.15.491856

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