Article

D2 autoreceptors gate vulnerability to cocaine use disorder

2026-03-11

Abstract excerpt

<h4>SUMMARY</h4> A defining feature of substance use disorder is that repeated drug use does not always lead to addiction, motivating the search for biomarkers of vulnerability 1 . Reduced striatal dopamine D2/3 receptor availability is a robust PET correlate of problematic stimulant use 2–5 , but the signal may reflect high endogenous dopamine level, and it conflates presynaptic D2 autoreceptors on dopamine ax...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 34f83aba-6e68-5f2b-ae8c-dc9ac41c7ee6
DOI: 10.64898/2026.03.10.710882

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

D2 autoreceptors gate vulnerability to cocaine use disorderDOI 10.64898/2026.03.10.710882Read

Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors.Semantic proximity Read

<i>Tmod2</i> is a regulator of cocaine responses through control of striatal and cortical excitability, and drug-induced plasticitySemantic proximity Read

Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.Semantic proximity Read

PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation.Semantic proximity Read

Hatching the behavioral addiction egg: Reward Deficiency Solution System (RDSS)™ as a function of dopaminergic neurogenetics and brain functional connectivity linking all addictions under a common rubricSemantic proximity Read

Genetics of dopamine receptors and drug addiction: a comprehensive review.Semantic proximity Read

Shifts in the neurobiological mechanisms motivating cocaine use with the development of an addiction-like phenotype in male rats.Semantic proximity Read

Region-Specific Regulation of Presynaptic Dopamine Homeostasis by D2 Autoreceptors Shapes the In Vivo Impact of the Neuropsychiatric Disease-Associated DAT Variant Val559.Semantic proximity Read

Leaky lessons learned: Efflux prone dopamine transporter variant reveals sex and circuit specific contributions of D2 receptor signalling to neuropsychiatric diseaseSemantic proximity Read

Heightened D3 dopamine receptor levels in cocaine dependence and contributions to the addiction behavioral phenotype: a positron emission tomography study with [11C]-+-PHNO.Semantic proximity Read

Genetics of dopamine receptors and drug addiction.Semantic proximity Read

Neurogenetics of Dopaminergic Receptor Supersensitivity in Activation of Brain Reward Circuitry and Relapse: Proposing “Deprivation-Amplification Relapse Therapy” (DART)Semantic proximity Read