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Article

Shifts in the neurobiological mechanisms motivating cocaine use with the development of an addiction-like phenotype in male rats.

Psychopharmacology - 1 Mar 2021

Lynch Wendy J, Bakhti-Suroosh Anousheh, Abel Jean M, Davis Camilla

Abstract excerpt

RATIONALE: The development of addiction is accompanied by a shift in the mechanisms motivating cocaine use from nucleus accumbens (NAc) dopamine D1 receptor (D1R) signaling to glutamate AMPA-kainate receptor (AMPA-R) signaling. OBJECTIVE: Here, we determined whether similar shifts occur for NAc-D2R signaling and following systemic manipulation of D1R, D2R, and AMPA-R signaling. METHODS: Male rats were given...

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Source

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Identifiers

PMID: 33241478
DOI: 10.1007/s00213-020-05732-4
PMCID: PMC8290931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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