Article

Increased number and activity of a lateral subpopulation of hypothalamic orexin/hypocretin neurons underlies the expression of an addicted state in rats

2018-06-27

Abstract excerpt

<h4>Background</h4> The orexin system is important for reward-driven motivation but has not been implicated in the expression of a multi-phenotype addicted state. <h4>Methods</h4> Rats were assessed for economic demand for cocaine prior to and following 14d of short- (ShA), long- (LgA) or intermittent-access (IntA) to cocaine. Rats were also assessed for a number of other DSM- V-relevant addiction criteria follo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 45c21fb9-2d13-5432-b00a-1eee2c18bd22
DOI: 10.1101/356220

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Increased number and activity of a lateral subpopulation of hypothalamic orexin/hypocretin neurons underlies the expression of an addicted state in ratsDOI 10.1101/356220Read

Demand elasticity predicts addiction endophenotypes and the therapeutic efficacy of an orexin/hypocretin-1 receptor antagonist in ratsSemantic proximity Read

The Role of Mesolimbic Reward Neurocircuitry in Prevention and Rescue of the Activity-Based Anorexia (ABA) Phenotype in Rats.Semantic proximity Read

A multi-symptomatic model of heroin use disorder in rats reveals distinct behavioral profiles and neuronal correlates of heroin vulnerability versus resiliencySemantic proximity Read

Reward Circuit Adaptations After Chronic Antipsychotic Treatment Confer Addiction VulnerabilitySemantic proximity Read

<i>Tmod2</i> is a regulator of cocaine responses through control of striatal and cortical excitability, and drug-induced plasticitySemantic proximity Read

Reward Circuitry Dopaminergic Activation Regulates Food and Drug Craving BehaviorSemantic proximity Read

κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction.Semantic proximity Read

Shifts in the neurobiological mechanisms motivating cocaine use with the development of an addiction-like phenotype in male rats.Semantic proximity Read

Opioid withdrawal engages a habenular subpopulation responsive to aversive statesSemantic proximity Read

Effects of access condition on substance use disorder-like phenotypes in male and female rats self-administering MDPV or cocaine.Semantic proximity Read

Behavioral and genetic markers of susceptibility to escalate fentanyl intakeSemantic proximity Read

Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same constructSemantic proximity Read