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Article

Substance use disorder a bio-directional subset of reward deficiency syndrome.

Frontiers in bioscience (Landmark edition) - 1 Jun 2017

Blum Kenneth, Gold Mark, Demetrovics Zsolt, Archer Trevor, Thanos Panayotis K, Baron David, Badgaiyan Rajendra D

Abstract excerpt

This commentary is to inform clinicians challenged with an increase in people seeking treatment for Substance Use Disorder (SUD), that the ninety percent revolving door, is, in part, due to post-withdrawal, untreated neurotoxicity. This impairment attenuates neurotransmitter signaling and compromises resting state functional connectivity, leading to unwanted sequelae including depression, sleep disturbances,...

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Identifiers

PMID: 28410131
DOI: 10.2741/4557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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