Article

RBBP6 activates the pre-mRNA 3’-end processing machinery in humans

2021-11-02

Abstract excerpt

3’-end processing of most human mRNAs is carried out by the cleavage and polyadenylation specificity factor (CPSF; CPF in yeast). Endonucleolytic cleavage of the nascent pre-mRNA defines the 3’-end of the mature transcript, which is important for mRNA localization, translation and stability. Cleavage must therefore be tightly regulated. Here, we reconstitute specific and efficient 3’-endonuclease activity of human...

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Literature Corpus work: 929779f0-6ad2-52bb-8c73-0c30f1927735
DOI: 10.1101/2021.11.02.466915

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