Article
Essential yeast protein with unexpected similarity to subunits of mammalian cleavage and polyadenylation specificity factor (CPSF).
Science (New York, N.Y.) - 29 Nov 1996
Chanfreau G, Noble S M, Guthrie C
Abstract excerpt
The 3' ends of most eukaryotic messenger RNAs are generated by internal cleavage and polyadenylation. In mammals, there is a strict dependence of both reactions on the sequence AAUAAA, which occurs upstream of polyadenylation [poly(A)] sites and which is recognized by CPSF. In contrast, cis-acting signals for yeast 3'-end generation are highly divergent from those of mammals, suggesting that trans-acting factors...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cattle
- Conserved Sequence
- Crystallography, X-Ray
- Fungal Proteins
- Molecular Sequence Data
- Mutation
- Poly A
- RNA Precursors
- RNA Processing, Post-Transcriptional
- RNA, Fungal
- RNA, Messenger
- RNA-Binding Proteins
- Saccharomyces cerevisiae
- mRNA Cleavage and Polyadenylation Factors